The Science Behind EMPWR+

Sulforaphane: Contains up to 100x more sulforaphane than mature broccoli, which is a powerful antioxidant that plays a role in chronic diseases, aging, and enhancing detoxification of the liver. Has potential risk-reduction effects in various cancers such as breast, prostate, lung, and colon by inhibiting the growth of cancer cells and inducing apoptosis in cancer cells. Sulforaphane also reduces inflammation in the body which can help lower blood pressure and relieve other chronic issues. By acting as an antioxidant and reducing inflammation in the brain, sulforaphane has the potential to help against neurodegenerative diseases such as Alzheimer’s and Parkinsons. By reducing cholesterol levels and blood pressure, sulforaphane supports heart health and reduces the risk of heart disease

Vitamin E: Contains up to 40x more Vitamin E than mature broccoli, which has been found to be very effective in preventing and reversing various disease complications due to its function as an antioxidant, its role in anti-inflammatory processes, and its immune-enhancing activity

Vitamin C: Contains up to 40x more Vitamin C than mature broccoli, which plays an important role as an antioxidant and can reduce the risk of chronic illness and aging. For immune health, vitamin C enhances the effects of immune cells and aids the body in defending against infections and illness. Vitamin C also plays a crucial role in skin health, wound healing, and connective tissue strength through collagen synthesis. Plays an important role in blood vessel health, blood pressure, and overall cardiovascular function. May lower the risk of vision loss in adults. 

Vitamin K: Contains up to 25x more Vitamin K than mature broccoli. Prevents excessive bleeding and supports wound healing. Activates a protein used in bone mineralization which supports bone health, reduces risk of fractures, and improves bone density. May protect against neurodegenerative diseases such as Alzheimer’s. 

Summary: 

The broccoli microgreen powder product provides immune support, reduces risk of chronic illnesses such as heart disease and neurodegenerative diseases, may reduce the risk of various cancers, and provides support against the effects of aging. Because it is so nutrient-rich, daily consumption will increase overall energy and well-being.

SFN=Sulforaphane

Isothiocynate - naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic, display anticarcinogenic activity because they reduce activation of carcinogens and increase their detoxification.

Sulforaphane is a type of isothiocyanate

Has insanely powerful antioxidant properties, including but not limited to anti-inflammatory and detoxification. Inflammation, though a natural response to heal from your immune system, can lead to many serious diseases such as cancer and cardiovascular disease if untreated.

Cardiovascular disease is the #1 killer in the US. Studies show that SFN consumption leads to lower risk of heart attack and stroke: 

  • Lower blood sugar
  • Lower oxidative stress (by deactivating inflammatory genes)
  • Reduce adhesive molecules that drive heart disease.

NRF2 Pathway - A major mechanism in the cellular defense against oxidative or electrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which controls the expression of genes whose protein products are involved in the detoxication and elimination of reactive oxidants and electrophilic agents 

Activation of the body’s NRF2 pathway, SFN is the most powerful natural activator of this mechanism that plays a huge role in regulating genes and cells against oxidants in the body. This can help remove toxins such as carcinogens from the body. It basically triggers crucial enzymes within the body that remove toxins such as carcinogens and restore damage to over 200 genes!

Age diseases all addressed by sulforaphane:

  • Risk of cancer
  • Cardiovascular disease
  • Neurodegenerative disease

Suppression of inflammation is the single most important predictor of not only increasing lifespan, but also cognition.

With SFN, NRF2 is activated every 80 minutes instead of 129 minute, boosting its activity by more than 35%.

Many people think of aging as something visible from the outside, however what’s most important, is the aging happening inside your body specifically to your cellular. Though SFN can help with some of the visible aging (skin, hair) what’s most important is the protection of what’s happening inside your body to your cells and genes. 

Brain and Cognitive Benefits

  • NRF2 is the body’s strongest defense of oxidative stress in the body.
  • This applies to serious conditions in the brain as well related diseases such as alzheimer's,autism, and even schizophrenia)

Mechanisms by which nutrition can have an effect on mental health and depression

  1. Affecting the production or function of neurotransmitters.
  2. By affecting systemic inflammation and the body’s immune system, which also affect brain function and neurotransmission. Inflammation is now known to play a role in depression.

Cruciferous vegetables (broccoli sprout) can lower inflammatory cytokines (proteins that trigger inflammation in the body) by up to 20%

In mice, the link between SFN and depression was tested. 

  • Mice were injected with a specific polysaccharide to induce inflammatory depressive behavior in the brain
  • They were then administer SFN over the course of 7 days
  • Results showed the reversal of depressive symptoms triggered by inflammation in the brain

This was compared to prescription antidepressants such as prozac. SFN showed similar effects on the brain in terms of reducing depressive/anxiety based behaviors in the brain.

Neurodegenerative diseases:

Brain inflammation and reactive oxygen species are hallmarks of neurodegenerative diseases and general brain aging diseases such as:

  • Alzheimer's disease
  • Parkinson’s disease
  • Huntington's disease

SFN given to mice has shown to improve spatial working memory and short term memory, even decreasing tremors and normalizing dopamine levels. 

  • Prevent death of neurons

Activates heat shock proteins, which has also shown to prevent the above mentioned neurodegenerative diseases.

These same effects can be studied in people with traumatic brain injuries. SFN increases neuroplasticity and helps promote the growth of new neurons in the brain.

RECAP:

  1. SFN and reduction of all cause mortality as well as cancerous diseases. SFN lowers DNA damage by reducing oxidative stress and inflammation. These processes are central to cancer, aging, neurodegenerative diseases, and more. 
  • Example: Broccoli sprouts increased excretion/removal of Benzene (a known carcinogen) in humans by 61%
  1. Broccoli sprouts contain 100x more glucoraphanin (precursor to sulforaphane) than their mature counterpart (regular broccoli)
  2. Cardiovascular health improved significantly by SFN.

**** NRF2 pathway is activated by SFN

DOSE: 

If someone wants to get the benefits of SFN, this is the recommended dosage:

1 gram of fresh broccoli sprout=0.425mg of SFN

60mg of SFN per day - 140g fresh broccoli per day (this is very high dose)

40mg is more obtainable and still shows VERY promising effects.

Broccoli or Sulforaphane: Is It the Source or Dose That Matters? - PMC (nih.gov)

Air pollution:

“A subsequent 12-week placebo-controlled, randomized clinical trial involving 291 participants from the same area using broccoli sprout beverages containing a combination of 40 μmol sulforaphane and 600 μmol glucoraphanin confirmed and extended these findings by showing that the excretion levels of the glutathione-derived conjugates of benzene and acrolein were significantly increased, by 61% and 23%, respectively in the volunteers who received the broccoli sprout beverage compared with placebo.”

General Effects:

“Global gene expression profiling to evaluate the transcriptional changes in the prostate of men at high risk for prostate cancer has revealed that consumption of broccoli-rich diets for 6- or 12 months associates with transcriptional changes in signaling pathways involved in inflammation and carcinogenesis in the prostate tissue; importantly, these changes are dose-dependently attenuated in subjects receiving the glucoraphanin-rich diet. Other pharmacodynamic effects of interventions with glucoraphanin/sulforaphane in humans include: Increase in the levels of reduced glutathione in brain, enhanced integration of fatty acid β-oxidation with TCA cycle activity, protection against skin erythema caused by exposure to ultraviolet radiation, reduction in plasma LDL-cholesterol, decrease in the levels of fasting blood glucose and glycated hemoglobin in obese patients with dysregulated type 2 diabetes, and improvements in social interaction, behavior, and verbal communication in young men with autism spectrum disorder.”

Carcinogen reduction: 

“The levels of aflatoxins from stored, subsistence seeds (corn and peanuts) in the Qidong area of coastal China near Shanghai, have in recent history been exceedingly high, as has associated incidence of liver cancer. Broccoli sprouts have been successfully piloted as a preventive intervention, and much data has been generated on safety and efficacy [biomarkers], as well as tolerance and acceptance by the local population;”

Arthritis:

“Early work by Healy and collaborators suggested an effect on shear stress in chondrocytes. This has now been followed by the elegant demonstration that increasing broccoli intake results in isothiocyanate (e.g., sulforaphane) uptake into the joint, with concomitant changes in the joint. Much other work on anti-inflammatory properties of sulforaphane may ultimately be related to arthritis;”

Cancer:

“A large variety of biomarkers have now been reported following sulforaphane treatment. The cancers being studied include: Breast, lung; gastric, colo-rectal, prostate, skin, head and neck , and liver;”